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1. Minimal Invasive Medical Devices

* Biodegradable electronics, Expandable devices, Biointerfaced electrodes



2. 4D Electronic Fabrication

* 4D Printing, Shape memory electronics



3. Electronics Reliability

* Active encapsulation, Next generation packaging



4. Smart Safety

* Smart sensing, Smart factory, Wearable IoT

1. Papers
*Wireless Bioresorbable Electronic System Enables Sustained Non-Pharmacological Neuroregenerative Therapy, Nature Medicine 24, 1830-1836 (2018)
* Advanced Materials and Devices for Bioresorbable Electronics, Accounts of Chemical Research 51, 988-998 (2018)
* Bioresorbable Silicon Electronic Sensors for the Brain, Nature 530, 71-76 (2016)
* Biodegradable Thin Metal Foils and Spin-On Glass Materials for Transient Electronics, Advanced Functional Materials 25, 1789-1797 (2015)
* Materials for Programmed, Functional Transformation in Transient Electronic Systems, Advanced Materials 27, 47-52 (2015)

2. Papers
* Implantable and Bioresorbable Sensors, 20170020402, 15/146,629, Jan 26, 2017
* Transient Electronic Devices Comprising Inorganic or Hybrid Inorganic and Organic Substrates and Encapsulates, 20170164482, 15/351,234, Jun 8, 2017

1. Biodegradable, minimally invasive implants

What happens if biomedical device and instruments are absorbed into the body after medical treatment? This eliminates the need for risky secondary surgery, which can potentially cause infection and hemorrhage, reduces patient cost and time, and improves the patient experience. Biodegradable, minimally invasive implants perform a series of research in design and fabrication of biomedical devices with fully biodegradable and resorbable materials, and in demonstrations in biological systems. The specific areas are understanding the mechanism of bioresorption of electronics, hybridizing soft substrate to inorganic electronics, and applying the developed electronics to demonstration biological systems.

2. Soft and conformal biomedical devices

How can medical services change by biomedical devices that can be integrated on or in the body? Here we highlight wearable/implantable bioelectronic devices that are soft, flexible and elastic so that they can be interfaced to tissue. This type of device let us perform biomedical diagnosis and treatment in a personal, mobile and real-time manner. Hybrids of inorganic electronic and soft organic substrates can provide high-performance electronics with flexible/conformal interfaces. We design various types of sensors such as body temperature, intra-cavity pressure, humidity, thermodiffusion, flow rate sensors to pH, glucose, and other biochemical sensors. This work also includes research on mechanical understanding on the deformation and human movement, and on fabrication methodologies for biomedical electronics.

3. Biomedical reliability of electronics

Malfunctions of biomedical devices are extremely critical in patient diagnosis and treatment, and thus the reliability of bioelectronics play an important role during the translational and commercialization stage of newly developed techniques. Biofluid, a mixture of various elements induces electrochemical reactions and the movement and metabolism of organ systems cause mechanical degradation. Biological immune reactions to foreign bodies must be considered for realization of medical tools. This topic covers understanding and evaluating the various factors that determine the lifetime and stability of implanted devices and providing methodologies to ameliorate reliability problems.