Seminar & Colloquium
[세미나: 1월 11일(목), 오전 10시] Prof. Yi Zhang, University of Connecticut, Storrs
Title
Implantable bioelectronics and microfluidics to unlock brain chemistry
Speaker
Prof. Yi Zhang, University of Connecticut, Storrs
Language
English
Biography
Dr. Yi Zhang is an Assistant Professor in the Department of Biomedical Engineering and the Institute of Materials Science at the University of Connecticut (UConn), Storrs. He received his Ph.D. degree in Chemical Engineering from the Georgia Institute of Technology in 2016, where he was awarded 2015 Waldemar T. Ziegler Award for Best Research Paper in Chemical Engineering and Exemplary Academic Achievement Award. He did his postdoc training in Prof. John A. Rogers group at Northwestern University from 2016 to 2018. Before joining UConn, he was an Assistant Professor at the University of Missouri, Columbia. His awards and honors include the NSF CAREER Award (2023), UConn-AAUP Research Excellence Award –Early Career (2023), UConn BME Early Career Faculty Scholar Award (2023), and the 2019 Biomedical Engineering Society Career Development Award. For more information, see: https://zhangyigroup.com/.
| Date | Thursday January 11st , 2024
| Time | 10:00 ~
| Venue | 온라인(https://snu-ac-kr.zoom.us/j/91222266925?pwd=UGxrcWlRaEM2NFA3Mnc3c2ZFOEFHQT09)
ID: 912 2226 6925
PW: 1010
[Abstract]
The human central nervous system contains billions of neurons that communicate through the propagation of action potentials along the cell membrane and the release, transport, and metabolism of neurochemicals at synapses. Technologies for in vivo electrophysiology have been intensively studied, with recent examples of Neuropixels 2.0 and Neural Matrix for recording over several thousand channels. Compared with these tools for electrophysiological recordings, the technologies for real-time neurochemical monitoring are very limited. Neurochemicals, however, have been found to play critical roles in reward signaling, learning, motor control, and treatments of neurological disorders, such as Parkinson’s disease, schizophrenia, and Alzheimer’s disease. Current technologies for neurochemical monitoring, such as microdialysis or fast-scan cyclic voltammetry (FSCV), have limited spatial and temporal precision or molecular specificity. The emerging genetically encoded fluorescent indicators offer high spatiotemporal monitoring. This technology, however, has limited translational potential due to complicated genetic modifications. In this presentation, I will present our recent developments on implantable bioelectronics and microfluidics to unlock brain chemistry, including 1) a soft implantable aptamer-graphene microtransistor probe for real-time monitoring of neurochemical release with nearly cellular-scale spatial resolution, high selectivity (dopamine sensor >19-fold over norepinephrine), and picomolar sensitivity, simultaneously (Nano Lett. 2022, 22, 9, 3668–3677), 2) a soft neural probe for multiplexed neurochemical monitoring via the electrografting-assisted site-selective functionalization of aptamers on graphene field-effect transistors (Analytical Chemistry 2022, 94 (24), 8605-8617), and 3) a wireless, programmable push-pull microsystem for membrane-free neurochemical sampling with cellular spatial resolution in freely moving animals (Science Advances 2022 8 (8), eabn2277). These new sets of implantable bioelectronics create opportunities for neuroscientists to understand where, when, and how the release of neurochemicals modulates diverse behavioral outputs of the brain.
| Host | 강승균 교수(02-880-5756)