logo

마이크로바이옴과 생노병사 Gut microbiome and animal physiology

Speaker

이원재, 서울대학교 생명과학부 교수

PROFESSIONAL EXPERIENCES

2011-현재: 서울대학교 생명과학부 교수

2015-현재: Hologenomics 창의연구단 단장 

2006- 2015: Symbiosystem 창의연구단 단장

2010-2011: 이화여대 생명과학부 석좌교수

2001-2010: 이화여대 생명과학부 부교수 및 교수

1996-2001: 연세대학교 의과대학 조교수

1994-1996: 프랑스 파스퇴르 연구소, post-doc

1994: 프랑스 파스퇴르 연구소-파리 제 6 대학, PhD. 

| Date | Wednesday, November 17th, 2021

| Time | 17:00 ~ 

| Venue | 온라인 강의 (https://snu-ac-kr.zoom.us/j/86516549039)로 출석확인 해주세요. 

Abstract

All metazoan guts have evolved to form a strategic alliance with indigenous microbiota. 

This evolutionarily-conserved mutualistic phenomenon has long-believed to be achieved by fine-tuned molecular interactions

 between the host and its microbiota. In fact, it has been observed that altered community structure of gut microbiota is likely to 

be associated with metabolic and/or inflammatory diseases such as obesity, diabetes, and inflammatory bowel diseases. 

However, the lack of understanding of critical genes in the microbiome and host genomes makes

 it difficult to explain the exact mechanism by which the gut microbiota impacts host health.

 The research on this issue has been hampered mainly by technical difficulties associated with in-depth integrated genetic

 analysis of both the microbes and host. To overcome these limitations, we have developed the combination of Drosophila 

and its commensal microbiota as a genetic model of host-microbe interaction which enabled us to perform a simultaneous 

genetic analysis of both host and microbe in an in vivo interacting condition. Using this Drosophila-microbiota in vivo interacting model 

system, we could identify commensal microbiomes involved in host development as well as bacterial microbiome involved in animal 

physiology. The straightforward simplicity of Drosophila-microbiota model system will provide a novel insight into the underlying 

mechanistic events to advance our knowledge in more complex vertebrate models, which will hopefully elucidate the unexpected 

roles of the microbiome in animal health and diseases. In this seminar, I will give an exciting example of such approaches, 

demonstrating the existence of a diet-microbiome-gut-brain axis capable of responding to essential amino acid deficit. 

| Host | Prof. Woong-Ryeol Yu (880-9096)