Seminar & Colloquium
[세미나: 6월 19일(월), 오후 4시] Prof. Kyung Soo Park, Harvard University
Title
Bone Marrow-derived Macrophages as a Potent Immune Initiator against Cancer.
Speaker
Prof. Kyung Soo Park, School of Engineering and Applied Sciences, Harvard University
EDUCATION
- 2006 ~ 2012 B.S., Chemical and Biomolecular Engineering, Sogang University, S Korea
- 2012 ~ 2014 M.S., Chemical and Biomolecular Engineering, Sogang University, S Korea
- 2015 ~ 2020 Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, Michigan
RESEARCH EXPERIENCE
- 2014 ~ 2015 Researcher, Advanced Bio-inspired Materials & Immunoengineering Laboratory, Sungkyunkwan
University, S Korea
- 2015. 01 ~ 2015. 05. Visiting student, Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard
University, Cambridge, Massachusetts
- 2020 ~ 2021 Postdoctoral fellow, Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan
- 2021 ~ present Postdoctoral fellow, School of Engineering and Applied Sciences, Harvard University, Allston,
Massachusetts
| Date | Monday, June 19th, 2023
| Time | 17:00 ~
| Venue | 신소재공동연구소(131동) 1층 세미나실(제1세미나실)
[Abstract]
Macrophages are one of the important immune cell types in cancer biology. Despite their abundance and ubiquitous presence in inflamed and infected tissues, macrophages have been largely neglected for their role in antigen presentation in part due to the perception that their key function is in innate immunity and that they are less efficient in antigen presentation compared to dendritic cells. However, being a professional antigen-presenting cell and an efficient phagocyte with a unique in vivo trafficking behavior, macrophages, upon engineering, have great potential to induce potent and multi-faceted immune responses against cancer. Macrophages that are differentiated from peripheral monocytes or bone-marrow cells through in vitro cultures have been leveraged to exert various functionalities upon in vivo administration depending on the pathological context. There are reports of macrophage usage in many applications, ranging from cancer diagnosis to therapeutics. Here, we investigated the potential of bone marrow-derived macrophages as a cell therapy against cancer, by demonstrating their use as a cell-based vaccine. Owing to their unique ability to infiltrate tissues, macrophages show a unique in vivo trafficking behavior and orchestrate the modulation of multiple stages of immune responses, providing a new platform for cancer vaccines that could be effective against tumors that have been less responsive to traditional cancer vaccines.
| Host | 도준상 교수 (02-880-1605)