Seminar & Colloquium
[세미나: 8월 1일(월), 오전 10시] 고정훈 박사, Caltech
Title
Protein-Polymer Conjugates for Enhanced Use of Therapeutic Proteins
Speaker
고정훈 박사, Department of Chemistry & Chemical Engineering, Caltech
Education
- June 2018 Ph.D. in Chemistry, University of California, Los Angeles
Advisor: Professor Heather D. Maynard
Dissertation title: Trehalose Polymers and Ruthenium-Catalyzed Polymerizations: Synthesis and Applications
- May 2013 B.S.E. in Biomedical Engineering and A.B. in Chemistry with Distinction, Duke University
Professional experiences
- 2020/7-2022/7 Postdoctoral researcher at Huntington Medical Research Institutes
- 2018/6- 2022/7 Visiting scientist/postdoctoral researcher at Div. of Chem. & Chem. Eng., Caltech
- 2013/9-2018/6 Graduate student researcher at Dept. of Chemistry & Biochemistry, UCLA
- 2016/6-2016/8 Visiting researcher at Dept. of Polymer Chemistry, Kyoto University
- 2012/8-2013/5 Independent study student at Dept. of Chemistry, Duke University
- 2011/7-2012/6 Student research intern at Dept. of Diag. Radiology, Yonsei Univ. College of Medicine
- 2008/3-2009/8 Independent study student at Dept. Biomedical Engineering, Duke University
| Date | Monday, August 1st, 2022
| Time | 10:00 ~
| Venue | 33동 223호 (동부 세미나실)
[Abstract]
Protein drugs are increasingly being used for treatment of various diseases, and success of antibody-based therapies has accelerated this trend. However, proteins suffer from poor physical stability during transport/storage and have short circulation half-life. This prevents the use of otherwise effective protein drugs in the clinic. One of the promising approaches is to conjugate synthetic polymer to these proteins to help improve their properties. In this talk, I will discuss some recent methods in bioconjugation that can be used to improve the delivery of therapeutic proteins. The examples include the glucose-responsive hydrogel for insulin delivery, a two-step conjugation strategy for efficient synthesis of a growth factor modified with both a positron emission tomography (PET) probe and a polymer to study the biodistribution of the conjugate, and a traceless linker whose release can be tuned and yield the original unmodified protein upon exposure to a desired stimulus. These techniques further expand the toolbox available to chemists for modifying proteins to render them more versatile in medical and bioengineering applications.
| Host | 권민상 교수 (02-880-8326)