Seminar & Colloquium
[세미나: 7월 12일(화), 오후 5시] Prof. Chang-Keun Lim, Nazarbayev University
Title
Reactive Oxygen Species Mediated Theranostic Materials
Speaker
Prof. Chang-Keun Lim, Department of Chemical and Materials Engineering, Nazarbayev University
Biography
Chang-Keun Lim is an assistant professor at the Department of Chemical and Materials Engineering, Nazarbayev University, and a principal investigator of the Photonic Materials and Biophotonics Laboratory since 2019. He obtained his Ph.D. in Materials Science and Engineering at Seoul National University with the thesis titled “Studies on Aggregation-Induced Fluorescence Modulation for Biological Application” under the supervision of Prof. Soo Young Park. He then developed his professional career at the Korea Institute of Science and Technology on photonic materials for biomedical applications as a postdoctoral researcher and SUNY at Buffalo on bio-nano interfacial materials, energy conversion materials, and perovskites as a research associate professor. His research background and interest are based on photo-active organic and organic-inorganic hybrid materials for biomedical and optoelectronic applications.
| Date | Tuesday, July 12th, 2022
| Time | 17:00 ~ 18:00
| Venue | 33동 223호 (동부 세미나실)
[Abstract]
Reactive oxygen species (ROS), including superoxide anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH-) and singlet oxygen (1O2), etc., are high-energy oxygen-bearing molecules that are often implicated as potent inducers of oxidative damage as well as mediators of aging and inflammation. Accordingly, ROS imaging is of great interest in the area of ‘molecular imaging’ which is a noninvasive visualization of disease-associated biological processes at the molecular and cellular levels in vivo. Simultaneously, an abnormally high concentration of ROS will trigger a programmed cell death to treat cells in disorder. In this presentation, ROS-mediated theranostic materials can image disease regions and treat them by in vivo overgeneration of ROS. We have explored fluorescence, chemiluminescence, resonance Raman scattering, and ultrasonic imaging modalities for diagnosis. While, for therapeutic purposes, efficiency improved photodynamic therapy (PDT), which can promote intersystem crossing to obtain a higher triplet electron population, has been explored in vitro and in vivo.
| Host | 박수영 교수(02-880-8327)