Seminar & Colloquium
[세미나: 7월 11일(월), 오후 4시] Harvard Medical School, Dr. Su Ryon Shin
Title
Engineering nano-biomaterials for tissue fabrication and regenerative medicine
Speaker
Harvard Medical School, Dr. Su Ryon Shin
Biography
Su Ryon Shin, PhD, received a doctoral degree from Hanyang University, South Korea. In 2010, she joined the staff at the Brigham and Harvard Medical School (HMS) as a postdoctoral research fellow in the Division of Engineering in Medicine. Shin was promoted to instructor at HMS in 2014 and became affiliated with the Harvard-MIT Division of Health Sciences and Technology. Today, Shin is an Assistant professor of medicine at the Brigham and HMS. Her interdisciplinary approach has earned her a growing international reputation for her work in nanomaterials science, regenerative medicine, and biomedical engineering. Her research focuses on developing micro- and nano-technologies to control cellular behavior, with particular emphasis on developing micro-scale biomaterials and engineering systems for various biomedical applications. Also, Dr. Shin has been developing and testing of integrated organs-on-chip systems with built-in biosensors. During her research period at the Brigham, Dr. Shin has been extremely prolific in her work, which has resulted in several funded grants by National Institutes of Health (NIH), American Heart Association (AHA), Air Force Office of Sponsored Research, Toyota Motor Corporation, and the Advanced Regenerative Manufacturing Institute of the U.S. Department of Defense, etc. In addition, she has published over 137 papers in peer-reviewed journals such as PNAS, Science Advanced, Advanced Materials, ACS Nano, Angewandte Chemie, etc. Her H index, which is a measure of scientific productivity, is already at 58. In just a few years she has been cited over 12,799 times. Her work has also attracted funding through the BWH Stepping Strong Innovator Awards and Innovation-Evergreen Award.
| Date | Monday, July 11th, 2022
| Time | 16:00 ~
| Venue | 장소: 33동 223호(동부세미나실)
[Abstract]
Damage and loss to muscles are common for survivors of trauma-related injuries and disease. In cases where a patient has damaged or lost a significant amount of muscle, the body is unable to repair or regain the lost tissue. Current treatment options are limited, and many patients must undergo multiple surgeries, which are costly and bear the significant risk to the patient. However, a few significant challenges in tissue engineering still exist, such as recapitulating the in vitro, 3D hierarchical microarchitecture comprised of multiple cell types and the extracellular matrix (ECM) components of native tissues and achieving the continuous function and viability of engineered tissues after implantation. To create biomimetic tissue constructs, we developed an advanced multi-material bioprinting platform that employs self-healing supporting baths and a programmable microfluidic device, which can easily and quickly switch between different materials, biological reagents, and cells. This advanced bioprinting platform allowed us to fabricate complex geometrical structures such as core-shell, donut shapes, and centimeter-sized biomimetic uni- or bi-cellular tissue constructs. Another challenge is the survival of bioprinted 3D tissue constructs at the injured area, which is fully dependent on the oxygenation derived by its connection to the blood circulation of the host body. The creation of a vascular network within engineered tissue constructs is time-consuming, which results in the failure of clinically sized implants due to starvation-induced cell death, especially in thick and large constructs. Therefore, incorporating functional vasculature or oxygenating biomaterials could potentially solve these problems, as it immediately allows for the perfusion of blood, thus offering instant and ample amounts of oxygen and nutrients. We have developed oxygen-generating biomaterials containing molecules that release oxygen upon hydrolysis for 2 weeks that allow the implant to survive their non-perfused phase and enable the continued function and maturation of living implants. The successful development of these innovative systems is expected to improve tissue regeneration significantly.
| Host | 선정윤 교수