Seminar & Colloquium
[세미나: 7월 14일(금), 오전 11시] Prof. Matthew W. Chang, National University of Singapore, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)
Title
Synthetic biology: from biomanufacturing to living medicine
Speaker
Prof. Matthew W. Chang, National University of Singapore, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)
Biography
Matthew Chang is Director of the Singapore Consortium for Synthetic Biology, Wilmar-NUS Corporate Laboratory, and NUS Synthetic Biology for Clinical and Technological Innovation, and Dean’s Chair in Medicine and Associate Professor of Biochemistry and Synthetic Biology at the Yong Loo Lin School of Medicine at the National University of Singapore. His research focuses on studying the engineering of biology to develop autonomous, programmable cells for biomedical and biomanufacturing applications. He co-founded the Global Biofoundry Alliance and the Asian Synthetic Biology Association and serves as Co-Chair of the World Economic Forum’s Global Future Council on Synthetic Biology.
| Date | Friday, July 14th, 2023
| Time | 11:00 ~
| Venue | 33동 328호
[Abstract]
Synthetic biology aims to engineer genetically modified biological systems that perform novel functions not found in nature, using reusable, standardized, and interchangeable biological parts. The utilization of these standard biological parts allows for the application of common engineering principles, such as standardization, decoupling, and abstraction, in the field of synthetic biology. By establishing this engineering framework, synthetic biology holds the potential to transform the construction of new biological systems into a predictable, reliable, and systematic process. While the development of most synthetic biological systems has traditionally been ad hoc, recent efforts to implement an engineering framework in synthetic biology have yielded long-awaited evidence that engineering principles can facilitate the creation of novel biological systems. Synthetic biology has already demonstrated its applicability to a wide range of fields, including energy, environment, and healthcare. In this presentation, I will discuss our recent advancements in the development of auto-regulatory genetic circuits that enable novel biological functions. A special focus will be given to our endeavors in transforming microbes into biotherapeutics, offering prophylactic and therapeutic efficacy against pathogenic infections and chronic metabolic diseases. This work establishes a solid foundation for engineering microbes to modulate host-microbiome interactions, providing support for the use of live biotherapeutics as a viable strategy for clinical intervention.
| Host | 남기태 교수(02-880-7079)