Seminar & Colloquium
[세미나: 3월 7일(화), 오전 10시] Prof. Edward S. Boyden, MIT
Title
Optical Tools for Analyzing and Repairing the Brain
Speaker
Prof. Edward S. Boyden, Y. Eva Tan Professor in Neurotechnology, MIT
Education
- 1999-2005 Ph.D. in Neurosciences, Stanford University
- 1995-1999 M.Eng., Electrical Engineering and Computer Science, Massachusetts Institute of Technology(MIT)
B.S., Electrical Engineering and Computer Science, Massachusetts Institute of Technology(MIT)
B.S., Physics, Massachusetts Institute of Technology(MIT)
- 1993-1995 Texas Academy of Mathematics and Science, University of North Texas
Professional Experience
- Massachusetts Institute of Technology, Cambridge, MA (July 2020-present)
Y. Eva Tan Professor in Neurotechnology at MIT
Howard Hughes Medical Institute, Investigator
Full Professor with Tenure, MIT Departments of Brain and Cognitive Sciences, Media Arts and Sciences, and Biological Engineering
Investigator, MIT McGovern Institute
Extramural Member, MIT Koch Institute for Integrative Cancer Research
Leader, Synthetic Neurobiology Group
Co-director, MIT Center for Neurobiological Engineering
Co-director, K. Lisa Yang Center for Bionics, MIT (2021-on)
- Massachusetts Institute of Technology, Cambridge, MA (July 2019-June 2020)
Y. Eva Tan Professor in Neurotechnology at MIT
Full Professor with Tenure, MIT Media Lab, MIT Departments of Biological Engineering and Brain and Cognitive Sciences
Investigator, MIT McGovern Institute
Extramural Member, MIT Koch Institute for Integrative Cancer Research
Leader, Synthetic Neurobiology Group
Co-director, MIT Center for Neurobiological Engineering
- Massachusetts Institute of Technology, Cambridge, MA (July 2014-Jun 2019)
Y. Eva Tan Professor in Neurotechnology at MIT (2018-on)
Associate Professor with Tenure, MIT Media Lab, MIT Departments of Biological Engineering and Brain and Cognitive Sciences
Investigator, MIT McGovern Institute
Extramural Member, MIT Koch Institute for Integrative Cancer Research (2017-on)
Leader, Synthetic Neurobiology Group
Co-director, MIT Center for Neurobiological Engineering
- Massachusetts Institute of Technology, Cambridge, MA (Jan 2011-Jun 2014)
Associate Professor, MIT Media Lab (Benesse Career Development Professor 2011-2013,
AT&T Career Development Professor, 2013-2014), MIT Departments of Biological Engineering and Brain and Cognitive Sciences
Investigator, MIT McGovern Institute
Leader, Synthetic Neurobiology Group
Co-director, MIT Center for Neurobiological Engineering (2013-on)
- Massachusetts Institute of Technology, Cambridge, MA (Jan 2007-Jan 2011)
Assistant Professor, MIT Media Lab (Benesse Career Development Professor), MIT
Department of Biological Engineering (2007-on), MIT Department of Brain and Cognitive Sciences (2008-on)
Investigator, MIT McGovern Institute (2010-on)
Leader, Synthetic Neurobiology Group
- Massachusetts Institute of Technology, Cambridge, MA (Nov 2006-Jan 2007)
Visiting Scientist, MIT Media Lab; Leader, Neuroengineering and Neuromedia Group
- Stanford University, Stanford, CA (Oct 2005-Oct 2006)
Helen Hay Whitney postdoctoral fellow, Depts. of Bioengineering, Applied Physics, Biological Sciences, with Drs. Mark Schnitzer and Karl Deisseroth
- Stanford University, Stanford, CA (Sep 1999-Oct 2005)
Hertz predoctoral fellow, NIH NRSA predoctoral fellow, Program in Neurosciences, Depts. of Molecular and Cellular Physiology and Neurobiology, with Drs. Jennifer Raymond and Richard Tsien.
| Date | Tuesday, March 7th, 2023
| Time | 10:00 ~
| Venue | 온라인 줌 회의 (https://snu-ac-kr.zoom.us/j/97411869558?pwd=eHJ4cDhpM1JxdENZU1pMMFRBdlNwQT09)
ID: 974 1186 9558
PW: 1010
[Abstract]
Understanding and repairing complex biological systems, such as the brain, requires technologies for systematically observing and controlling these systems. We are discovering new molecular principles that enable such technologies. For example, we discovered that one can physically magnify biological specimens by synthesizing dense networks of swellable polymer throughout them, and then chemically processing the specimens to isotropically swell them. This method, which we call expansion microscopy, enables ordinary microscopes to do nanoimaging – important for mapping molecules throughout cells, and cells throughout brain circuits. Expansion of biomolecules away from each other also decrowds them, enabling previously invisible nanostructures to be labeled, and seen. As a second example, we discovered that microbial opsins, genetically expressed in neurons, could enable their electrical activities to be precisely controlled in response to light. These molecules, called optogenetic tools, enable causal assessment of how neurons contribute to behaviors and pathological states, and are yielding insights into new treatment strategies for brain diseases. They are also beginning to be used in human patients, in experimental clinical contexts like treating blindness. Finally, we are developing, using new strategies such as robotic directed evolution, fluorescent reporters that enable the precision measurement of signals such as voltage. In order to reveal relationships between different molecular signals within a cell, we are developing spatial and temporal multiplexing strategies that enable many such signals to be imaged at once in the same living cell, using ordinary microscopes, and requiring only fully genetically encoded constructs. We share all these tools freely, and aim to integrate the use of these tools so as to enable comprehensive understandings of neural circuits.
| Host | 강승균 교수(02-880-5756)